In practice, (and yes, there are always exceptions to be found) BYOB is rarely used to any measurable benefit. The API is substantially more complex than default reads, requiring a separate reader type (ReadableStreamBYOBReader) and other specialized classes (e.g. ReadableStreamBYOBRequest), careful buffer lifecycle management, and understanding of ArrayBuffer detachment semantics. When you pass a buffer to a BYOB read, the buffer becomes detached — transferred to the stream — and you get back a different view over potentially different memory. This transfer-based model is error-prone and confusing:
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Source: Computational Materials Science, Volume 267